The association of short sleep after acute coronary syndrome with recurrent cardiac events and mortality.

Short sleep duration (less than 7 hours per night), is associated with a range of physiologic responses (eg, inflammation, impaired glucose tolerance, reduced insulin sensitivity, and appetite regulation), health behaviors, and comorbidities (eg, poor diet, diabetes, metabolic syndrome, obesity, and hypertension) that increase risk of coronary heart disease (CHD).2-6 A meta-analysis of prospective cohort studies found that self-reported short sleep was associated with a 48% increased risk of incident CHD.5 Short sleep is also common among post-ACS patients.7,8 However, no study has examined whether short sleep is associated with risk in ACS patients. We hypothesized that ACS patients who report short sleep duration in the month after ACS would be at increased risk for 1-year ACS recurrence and mortality relative to those who report sleeping 7 hours or more per night.